Sequence Bio is a genomics-driven drug discovery company based in St. John's, NL, Canada, focused on identifying the true genetic signals of disease to enable the development of more effective therapies. Sequence Bio leverages unique genetic data from the Newfoundland population—known for its founder effect—to improve drug target discovery and increase the success rate of new drug development.
The company addresses a major challenge in the pharmaceutical industry: approximately 90% of drug candidates fail in development, often due to poorly understood disease mechanisms. Sequence Bio aims to overcome this by harnessing large-scale genetic research and advanced analytics to discover more reliable drug targets. Their approach is built on the insight that drug candidates linked to strong genetic evidence are significantly more likely to deliver meaningful clinical results.
The Technology That Enabled Sequence Bio
Sequence Bio's platform utilizes genomic sequencing and population-scale data analysis, with a special focus on the unique genetics of individuals from Newfoundland. The "founder effect" in this region means a relatively homogenous gene pool, which can make disease-related genetic signals clearer and more actionable for research. By combining this with advanced bioinformatics, Sequence Bio helps identify drug targets that are both novel and clinically relevant.
Who Uses Sequence Bio?
Sequence Bio primarily serves pharmaceutical and biotechnology companies seeking to improve their drug discovery pipelines. Their technology is designed for organizations looking to identify more precise drug targets, reduce time and costs in early-stage drug development, and increase the likelihood of clinical success. They are part of a broader movement towards data-driven, genetics-enabled drug discovery.
Who Are Sequence Bio's Competitors?
Sequence Bio operates in the competitive genomics and therapeutics sector. Key competitors and comparable companies include:
- AstraZeneca: A global pharmaceutical leader with significant investment in genetics-driven drug discovery, integrating human genetics with biology to find more effective targets.
- Sanogenetics: Focuses on leveraging genomic and proteomic data to guide drug target identification and validation, emphasizing the transition from genetic insights to therapeutic development.
Other companies in the space include 23andMe (therapeutics division), deCODE genetics, and Regeneron Genetics Center, each bringing different population datasets or analytical strengths to the drug target discovery process.
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